Want to Live a Long, Healthy Life? Here’s What One Top Doctor Actually Does

Who doesn’t dream of living well into their 90s—sharp, active, and healthy? Imagine aging like Betty White with her quick wit, channeling Toni Morrison’s eloquence, or matching Jimmy Carter’s civic drive into your golden years. While it’s easy to assume that kind of vitality depends on winning the genetic lottery, one renowned doctor says that’s not the whole story.

Dr. Eric Topol, a leading cardiologist and founder of the Scripps Research Translational Institute in California, has spent nearly two decades studying people who defy aging stereotypes. His ongoing research—the Wellderly Study—follows more than 1,400 so-called Super Agers: individuals 80 and older who’ve managed to dodge three of the most common chronic conditions—cancer, heart disease, and neurodegenerative disease.

The Surprising Truth About Longevity

Here’s the kicker: When Topol’s team conducted full genetic sequencing on all 1,400 Super Agers, they found no universal genetic factor that explained their remarkable health.

In other words, genes aren’t your destiny.

Instead, Topol’s new book, Super Agers: An Evidence-Based Approach to Longevity, dives into what does make the difference—and how modern science can help us live longer, healthier lives. Spoiler: it’s not magic. It’s measurable.

The Real Longevity Formula: Lifestyle + Technology

Topol points to key lifestyle habits and emerging technologies that together create the foundation for longevity:

• Diet, exercise, and sleep: These remain the pillars of healthy aging, supported by decades of research.
• Polygenic risk scores: These genetic tools help predict disease risk based on a combination of gene variants—not just one.
• Organ clocks via ‘omics’: New techniques in proteomics (analyzing all the proteins in your body) can now estimate how fast your organs are aging.
• Artificial intelligence: AI is being used to pull together all your health data—from lab tests to genetic reports—to predict and prevent disease more effectively.

While not everyone may become a Super Ager, Topol emphasizes that these tools can help extend your health span—the number of years you live free of serious illness—even if you don’t reach 100.

The Doctor’s Own Longevity Plan

Topol isn’t just talking the talk—he’s living it. Now 71, he’s made real changes to his own daily routine in the hopes of staying disease-free well into his 80s.

“I hope to be a Super Ager,” he said in a recent interview on CNN’s Chasing Life podcast with Dr. Sanjay Gupta. “If I can get another 10 or 15 years without an age-related disease, that’d be great. And I’ve really doubled down on the things that I can do to help get there.”

So What Can You Do?

You don’t need to be a scientist to take steps toward a longer, healthier life. According to Topol’s findings, focusing on the basics—moving regularly, sleeping well, eating wisely, and monitoring your health proactively—can go a long way.

And with new technology making it easier to understand and track your personal health risks, aging well might just be a science after all.